Palisaded encapsulated neuroma (PEN) is a benign cutaneous or mucosal neural tumor which, usually, presents as a solitary, firm, asymptomatic, papule or nodule showing striking predilection for the face.It occurs commonly in middle age, and there is no sex predilection.Oral PEN are not common, and these lesions Bitter Melon must be distinguished from other peripheral nerve sheath tumors such as the neurofibroma, neurilemma (schwannoma), and traumatic neuroma.
The major challenge in dealing with lesions of PEN is to avoid the misdiagnosis of neural tumors that may be associated with systemic syndromes such as neurofibromatosis and multiple endocrine neoplasia syndrome type 2B.Here, we present a case of benign PEN SLA/GEL of the gingiva in the left anterior mandibular region, laying importance on immunohistochemical staining in diagnosing such lesions.